反应详情

温度

50 °C

The pure tert-butyl (1R,2S)-1-hydroxy-1-phenylpentan-2-ylcarbamate was dissolved in ethyl acetate (1.2 ml). Water (50 μl) and hydrochloric acid in ethyl acetate (1.0 ml, 1.5 M) were added. The solution was stirred at 50° C. for 90 min. A precipitation was formed. The volume was reduced to ⅔ by heavy stirring and a stream of argon gas. The stirring was continued for 1 h at r.t. The suspension was filtered and the solid was dried at 50° C. under reduced pressure for 2 h.

1. customA precipitation
2. customwas formed
3. stirringby heavy stirring
4. waitThe stirring was continued for 1 h at r.t
5. filtrationThe suspension was filtered
6. customthe solid was dried at 50° C. under reduced pressure for 2 h.