Lithium Hydroxide → HCID 59732414, compound

HRID 131198Notes

Reaction equation

HRID 131198 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:7]2[S:21][CH:20]=[CH:19][C:8]=2[N:9]=[C:10]([CH2:12][CH2:13][C:14]([O:16]CC)=[O:15])[N:11]=1.[OH-].[Li+]>C1COCC1.O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:7]2[S:21][CH:20]=[CH:19][C:8]=2[N:9]=[C:10]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[N:11]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 59732296HCID 59732296, compound

Product 1

HCID 59732414HCID 59732414, compoundYield 82.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl 3-(4-(2-furyl)thieno[3,2-d]pyrimidine-2-yl)propionate (0.07 g, 0.23 mmol) in THF (1.0 mL) and water (1.0 mL) was treated with lithium hydroxide (0.10 g, 2.32 mmol), stirred at room temperature for 16 h, concentrated in vacuo, dissolved in water, acidified to pH 2 by the addition of HCl (0.1 mL, 6.0-M), cooled in ice and filtered to give the title compound (0.052 g, 81%) as a white solid.

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutiondissolved in water
  3. additionacidified to pH 2 by the addition of HCl (0.1 mL, 6.0-M)
  4. temperaturecooled in ice
  5. filtrationfiltered

Sources & evidence

ORD record
ord-a8fc51ad6b9f4432bd8745d5a15acd20
Source dataset
uspto-grants-2008_06
Patent number
US07384949B2

Reaction notes

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