反应详情

Suspend 2-(5-fluoro-2-nitro-phenylamino)-thiophene-3-carbonitrile (3.89 g, 14.78 mmol) in ethanol (40.0 ml). Dissolve tin(II) chloride dihydrate (10.00 g, 44.33 mmol) in 5N HCl (40.0 ml) and then add it to the suspension. Heat the reaction at reflux for 2.5 hours and then cool it to ambient temperature. Collect the resulting precipitate by vacuum filtration and then dry it under vacuum to give 3.32 g (83%) of the title compound: mass spectrum (ion spray): m/z=234.1 (M+1).

1. temperatureHeat
2. customthe reaction
3. temperatureat reflux for 2.5 hours
4. customCollect the resulting precipitate
5. filtrationby vacuum filtration
6. customdry it under vacuum