反应详情

温度

100 °C

2-Fluoro-5-iodobenzaldehyde (527 mg, 2.11 mmol), 2-hydrazinopyridine (237 mg, 2.17 mmol), cesium carbonate (2.06 g, 6.32 mmol) and NMP (10 ml) werer charged in a 10 ml vial which was sealed and stirred (magnetic bar) over night at 100° C. Water and ethylacetate were added and the phases was separated. The organic layer was washed three times with brine and concentrated. Purification on silica with ethylacetate:heptane 5:95 to 10:90 over 15 min, 10 ml/min, followed by evaporation afforded 31 mg (5%) of 5-iodo-1-pyridin-2-yl-1H-indazole.

1. customwas sealed
2. customthe phases was separated
3. washThe organic layer was washed three times with brine
4. concentrationconcentrated
5. customPurification on silica with ethylacetate:heptane 5:95 to 10:90 over 15 min
6. custom10 ml/min, followed by evaporation