反应详情

温度

100 °C

A mixture of the product of example 10 part b) (279 mg), 2-bromopyrimidine (300 mg), copper(I) iodide (95 mg), trans-cyclohexanediamine (55 mg) and potassium carbonate (300 mg) in dioxane (2 ml) was heated at 100° C. for 16 hours under nitrogen. The reaction mixture was concentrated to dryness and purified by silica chromatography eluting with an ethyl acetate to 10% methanol/ethyl acetate gradient, followed by RPHPLC to give the title compound as a white solid (105 mg).

1. concentrationThe reaction mixture was concentrated to dryness
2. custompurified by silica chromatography
3. washeluting with an ethyl acetate to 10% methanol/ethyl acetate gradient