反应详情

Potassium carbonate (3.4 g, 25 mmol) was added to a mixture of N-Boc-piperazine (3.0 g, 16 mmol) in acetonitrile (20 mL). Methyl bromoacetate (1.5 mL, 16 mmol) was added to the mixture. Reaction stirred at room temperature for 1.5 hours. Mixture was filtered over celite. Filtrate was concentrated in vacuo. Residue was treated with diethyl ether (10 mL), filtered and concentrated in vacuo. Bulb to bulb distillation (165° C. at 700 mtorr) gave the title compound as clear colorless oil in 60% yield. MS m/e (M+H)+=259.4.

1. customReaction
2. filtrationMixture was filtered over celite
3. concentrationFiltrate was concentrated in vacuo
4. additionResidue was treated with diethyl ether (10 mL)
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. distillationBulb to bulb distillation (165° C. at 700 mtorr)