Chlorosuccinimide → HCID 136334118, compound

HRID 132515Notes

Reaction equation

HRID 132515 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]3[NH:17][CH2:16][CH2:15][CH2:14][N:10]3[C:11](=[O:13])[CH:12]=2)=[N:3][CH:2]=1.[Cl:18]N1C(=O)CCC1=O>C(O)(=O)C>[Cl:18][C:12]1[C:11](=[O:13])[N:10]2[CH2:14][CH2:15][CH2:16][NH:17][C:9]2=[N:8][C:7]=1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][N:3]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 135602108HCID 135602108, compound

Product 1

HCID 136334118HCID 136334118, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of 3.0 g (13.09 mmol) of 2-(pyrimidin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one in 60 ml of acetic acid was treated with 1.75 g (15.7 mmol) of N-chlorosuccinimide. The reaction mixture was heated at 90° C. during 18 h.

Sources & evidence

ORD record
ord-b869f96b244b44c3a8b7079841017ce2
Source dataset
uspto-grants-2008_06
Patent number
US07388005B2

Reaction notes

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