反应详情

温度

22.5 °C

0.4 g (1.2 mmol) of the compound from Example 2 was added to a slurry of 0.04 g (1.32 mmol) of NaH (95% pure) in 50 ml of dimethylformamide (DMF), and the mixture was then stirred at 20-25° C. for 10 min. A solution of 0.17 g (1.2 mmol) of iodomethane in 10 ml of DMF was then added dropwise, and the combined reaction solution was stirred at 20-25° C. for about 18 hours, poured into water and then extracted with MtBE. The the organic phases were washed with water and then dried. Removal of the solvent gave 0.3 g of the title compound as a viscous oil.

1. customthe combined reaction solution
2. stirringwas stirred at 20-25° C. for about 18 hours
3. extractionextracted with MtBE
4. washThe the organic phases were washed with water
5. customdried
6. customRemoval of the solvent