Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1325995Notes

Reaction equation

HRID 1325995 reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>COCCOCCOC.COc1cc(C(c2ccccc2)c2ccccc2)c(N2C=CN(c3c(C(c4ccccc4)c4ccccc4)cc(OC)cc3C(c3ccccc3)c3ccccc3)C2)c(C(c2ccccc2)c2ccccc2)c1.CS(C)=O.C[Si](C)(C)[O-].[Cu][Br].[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Participants

10

Reactant 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Product 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineYield 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineYield 0%

Reagents, catalysts & solvents 5

HCID 23672319Sodium trimethylsilanolateReagentHCID 24593copper(I) bromideCatalystHCID 102190031HCID 102190031, compoundCatalystHCID 679Dimethyl SulfoxideSolvent5×HCID 8150DiglymeSolvent5×

Conditions

Temperature
60 °C

Workup

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Sources & evidence

ORD record
ord-45b3eb6f8d9c4e3f96d504a7d029056a
Source dataset
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Original link
View source

Reaction notes

Loading…