反应详情

In N2 atmosphere free of water and oxygen, to a reactor were successively added 0.02 mol 3-ethyl-2,4-pentanediol, 20 ml THF, and 0.06 mol pyridine, then slowly added dropwise 0.05 mol benzoyl chloride. The reaction was heated refluxing for 8 hours, and allowed to continue at room temperature for further 12 hours. After the reaction was finished, the reaction mixture was filtered and the cake was washed with anhydrous ethyl ether for three times. The organic phase was completely washed with saturated saline, and dried over anhydrous sodium sulfate. Removing the solvent gave 5.1 g product.

1. temperatureThe reaction was heated
2. temperaturerefluxing for 8 hours
3. filtrationthe reaction mixture was filtered
4. washthe cake was washed with anhydrous ethyl ether for three times
5. washThe organic phase was completely washed with saturated saline
6. dry with materialdried over anhydrous sodium sulfate
7. customRemoving the solvent