HRID132797

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14232

N-Methoxymethylamine

C2H7NO

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)O

HCID2779009

N-[tert-Butoxy(hydroxy)methylidene]-3,5-difluorophenylalanine

C14H17F2NO4

HCID178418507

未命名化合物

PRODUCTS

生成物

结构：C=CC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)OC(C)(C)C

HCID86591229

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

N-(tert-butoxycarbonyl)-3,5-difluoro-L-phenylalanine (1) is coupled to N-methyl-N-methoxylamine using the carbodimide EDC in the presence of HOBT in DMF. The “Weinreb” amide product (m.p. 48° C.) is then treated with vinylmagnesium bromide in THF at 0° C. for 2 hr. Workup provided vinyl ketone 2 (m.p. 115° C.).