Hydrazine hydrate (1:1) → HCID 10149166, compound

HRID 133002Notes

Reaction equation

HRID 133002 reaction equation
I[C:2]1[C:7]2[C:8](=O)[C:9]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17]C(=O)OCC4C=CC=CC=4)[C:10]=3[CH2:11][CH2:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.O.[NH2:30][NH2:31]>>[N:30]1[NH:31][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[CH2:12][CH2:11][C:10]4=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=[C:9]4[C:8]=1[C:7]=23

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58646840HCID 58646840, compound

Product 1

HCID 10149166HCID 10149166, compound

Procedure

50 mg of benzyl N-(6-iodo-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)carbamate prepared in Example 8-a was treated with hydrazine monohydrate by the procedure of Example 1-h and purified and separated by silica gel column chromatography (ethyl acetate:hexane=1:2), to give 15 mg of the title compound as a colorless powder.

Workup

  1. custompurified
  2. customseparated by silica gel column chromatography (ethyl acetate:hexane=1:2)

Sources & evidence

ORD record
ord-07156b2ce8cf4e15bc6cb4a3013953af
Source dataset
uspto-grants-2008_06
Patent number
US07390797B2

Reaction notes

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