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HRID133113

反应详情

EQUATION

反应方程式

HRID 133113 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1ccncc1
HCID13389

Pyridin-4-carboxaldehyde

C6H5NO

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：CC(C)(C)c1ccc(N2CCc3cccc(N)c3C2=O)cc1
HCID69159346

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1ccc(N2CCc3cccc(NCc4ccncc4)c3C2=O)cc1
HCID11639602

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of the amine (Step E) and CH2Cl2 (5 mL) was added 4-pyridinecarboxaldehyde and NaBH(OAc)3. The reaction was stirred at RT for 18 h. Purification by silica flash chromatography (25-75% EtOAc:hexane) gave the desired product as a light-yellow oil. MS m/e 386 (M+H)+. Calc'd for C25H27N3O-385.50.

WORKUP

后处理

  1. customPurification by silica flash chromatography (25-75% EtOAc:hexane)