3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1333096노트

반응식

HRID 1333096 반응식
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>c1ccc(P(c2ccccc2)c2ccccc2P(c2ccccc2)c2ccccc2)cc1.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CS(C)=O.CS(C)=O.CS(C)=O.CS(C)=O.CS(C)=O>Cn1c(=O)c2c(ncn2C)n(C)c1=O.c1ccc(C2CCN(c3cccnc3)CC2)cc1.c1ccc(C2CCN(c3ccncc3)CC2)cc1

참가 물질

8

반응물 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

생성물 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine수율 0%HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridine수율 0%

시약·촉매·용매 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramine시약HCID 4983791,2-Bis(diphenylphosphino)benzene촉매HCID 679Dimethyl Sulfoxide용매5회

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온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-e5bb8a3a6f9f494e9e96bddeb2036c4a
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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