3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine

HRID 1334997노트

반응식

HRID 1334997 반응식
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC#[N]->[Cu+](<-[N]#CC)(<-[N]#CC)<-[N]#CC.CS(C)=O.C[Si](C)(C)[O-].O=S(=O)([O-])C(F)(F)F.[Na+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

참가 물질

9

반응물 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

생성물 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine수율 0%HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridine수율 0.813%

시약·촉매·용매 4

HCID 23672319Sodium trimethylsilanolate시약HCID 75806Tricyclohexylphosphine촉매HCID 178465520HCID 178465520, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

반응 조건

온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-df24da950f734ce3945c934b3ffb5e00
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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