Trifluoroacetic acid → Trifluoroacetic acid

HRID 133791Notes

Reaction equation

HRID 133791 reaction equation
[C:1]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([CH2:12][C:13](=[N:30]C(=O)OC(C)(C)C)[NH:14][C:15](=[O:29])[CH2:16][C:17](=[N:26][O:27][CH3:28])[C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[CH:7][C:6]=1[Cl:38])(=[O:3])[CH3:2].[C:39]([OH:45])([C:41]([F:44])([F:43])[F:42])=[O:40]>ClCCl>[C:1]([NH:4][C:5]1[C:6]([Cl:38])=[CH:7][C:8]([CH2:12][C:13](=[N:14][C:15](=[O:29])[CH2:16][C:17](=[N:26][O:27][CH3:28])[C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[NH2:30])=[CH:9][C:10]=1[Cl:11])(=[O:3])[CH3:2].[C:39]([OH:45])([C:41]([F:44])([F:43])[F:42])=[O:40]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86615410HCID 86615410, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 73320112HCID 73320112, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-(4-acetamido-3,5-dichlorophenyl)-1-(3-(methoxyimino)-3-(4-methoxyphenyl)-propanamido)ethylidenecarbamate (12 mg) in dichloromethane (0.10 mL) was added TFA (0.10 mL), and the resulting mixture was stirred at room temperature for 12 h. The solvents were removed in vacuo to give the title compound as its TFA salt (10 mg). Retention time: 1.75 min (method A). MS (ESI) (M+H)+ 482.19.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-ad41e7a820c846878685a87a3e3e3769
Source dataset
uspto-grants-2008_06
Patent number
US07390925B2

Reaction notes

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