反应详情

9.0 g of imidazole and 15.9 g of t-butyldimethylsilyl chloride were added in order to a dimethylformamide (180 ml) solution of 9.0 g of 3-hydroxydihydrofuran-2-(3H)-one, and the reaction liquid was stirred for 1 hour at room temperature. The reaction liquid was diluted with ethyl acetate, washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to obtain the entitled compound as a colorless oily substance.

1. customthe reaction liquid
2. customThe reaction liquid
3. washwashed with water
4. dry with materialdried with anhydrous sodium sulfate
5. customThe solvent was evaporated away under reduced pressure
6. customthe resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1)
7. customto obtain the entitled compound as a colorless oily substance