Dichloromethane → 5-(3,3-dimethyl-but-1-ynyl)-3-(N-tert-butoxycarbonyl-piperidin-4-yl)amino-thiophene-2-carboxylic acid methyl ester

HRID 134003Notes

Reaction equation

HRID 134003 reaction equation
[C:17]([CH3:18])([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]1.[CH2:31]([Sn:32]([Cl:33])([Cl:34])[CH2:35][CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH3:41].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7]([C:11]#[C:12][C:13]([CH3:14])([CH3:15])[CH3:16])[cH:8][c:9]1[NH2:10].[Cl:54][CH2:55][Cl:56].[c:42]1([SiH3:43])[cH:44][cH:45][cH:46][cH:47][cH:48]1>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7]([C:11]#[C:12][C:13]([CH3:14])([CH3:15])[CH3:16])[cH:8][c:9]1[NH:10][CH:27]1[CH2:26][CH2:25][N:24]([C:22]([O:21][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:23])[CH2:29][CH2:28]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 12688Dibutyltin dichlorideHCID 12752PhenylsilaneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 24989346Methyl 3-amino-5-(3,3-dimethylbut-1-yn-1-yl)thiophene-2-carboxylate

Product 1

HCID 666035305-(3,3-dimethyl-but-1-ynyl)-3-(N-tert-butoxycarbonyl-piperidin-4-yl)amino-thiophene-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-2d860f1b02c54a4687e312dc96ce1d4e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…