N,N-Dimethyl-1,3-propanediamine → 6-chloro-4'-{5-chloro-2-[1-(3-dimethylamino-propylcarbamoyl)-1-methyl-ethoxy]-phenyl}-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
Reaction equation
[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH3:58][N:59]([CH2:60][CH2:61][CH2:62][NH2:63])[CH3:64].[CH:49]([N:50]([CH2:51][CH3:52])[CH:53]([CH3:54])[CH3:55])([CH3:56])[CH3:57].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:31]2[c:32]([CH3:38])[cH:33][cH:34][c:35]([F:37])[cH:36]2)[NH:13][C:14](=[O:30])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][OH:27])([CH3:28])[CH3:29])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[OH:39][n:40]1[c:41]2[c:42]([cH:43][cH:44][cH:45][cH:46]2)[n:47][n:48]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:31]2[c:32]([CH3:38])[cH:33][cH:34][c:35]([F:37])[cH:36]2)[NH:13][C:14](=[O:30])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([C:26](=[O:27])[NH:63][CH2:62][CH2:61][CH2:60][N:59]([CH3:58])[CH3:64])([CH3:28])[CH3:29])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-022c0daef6664ed2b5daa5774e37d181
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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