反应详情

2.56 g of pyrazine-2-carboxylic acid and 4.66 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (20 ml) solution of 3.7 g of 4-amino-2-fluoro-N-methoxy-N-methylbenzamide, and the reaction liquid was stirred at room temperature for 1 hour. Pyridine was evaporated away under reduced pressure, and the residue was diluted with ethyl acetate, washed with water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting solid was washed with a mixed solvent of ethyl acetate and hexane to obtain the entitled compound as a pale yellow solid.

1. customthe reaction liquid
2. customPyridine was evaporated away under reduced pressure
3. additionthe residue was diluted with ethyl acetate
4. washwashed with water
5. dry with materialdried with anhydrous magnesium sulfate
6. customThe solvent was evaporated away under reduced pressure
7. washthe resulting solid was washed with a mixed solvent of ethyl acetate and hexane