Acetic Acid → Tert-butyl 4-[(pyridin-3-yl)amino]piperidine-1-carboxylate

HRID 134444Notes

Reaction equation

HRID 134444 reaction equation
[C:30]([O:31][BH-:32]([O:33][C:34](=[O:35])[CH3:36])[O:37][C:38](=[O:39])[CH3:40])(=[O:41])[CH3:42].[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[N:15]1[CH2:16][CH2:17][C:18](=[O:21])[CH2:19][CH2:20]1.[CH3:22][C:23](=[O:24])[OH:25].[Cl-:44].[Cl:26][CH:27]([Cl:28])[CH3:29].[NH2:1][c:2]1[cH:3][n:4][cH:5][cH:6][cH:7]1.[Na+:43].[Na+:45]>>[NH:1]([c:2]1[cH:3][n:4][cH:5][cH:6][cH:7]1)[CH:18]1[CH2:17][CH2:16][N:15]([C:13]([O:12][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:14])[CH2:20][CH2:19]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 312ChlorideHCID 923Sodium ion2×HCID 63651,1-DichloroethaneHCID 100093-AminopyridineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 22499486Tert-butyl 4-[(pyridin-3-yl)amino]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-29515d1ee56d40dc8789871ec88c4a61
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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