反应详情

The mixture containing 2-[(4-bromophenyl)amino]benzoxazol-5-ol (1 eq), potassium bis(trimethylsilyl)amide (4 eq), was stirred in dimethylformamide for 30 min at room temperature. To this mixture was added (4-chloro(2-pyridyl)-N-methylcarboxamide (1 eq) and Potassium carbonate (1.2 eq) and microwaved for 6 mins at 150° C. The reaction mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was separated and washed with brine, dried, filtered and concentrated. Purification on Prep LC yielded the desired product. MS: MH+=439.

1. custommicrowaved for 6 mins at 150° C
2. concentrationThe reaction mixture was then concentrated
3. custompartitioned between ethyl acetate and water
4. customThe organic layer was separated
5. washwashed with brine
6. customdried
7. filtrationfiltered
8. concentrationconcentrated
9. customPurification on Prep LC