Iodoethane → HCID 57617719, compound

HRID 1348594Notes

Reaction equation

I[CH2:2][CH3:3].[C:4]([O:8][C:9](=[O:23])[NH:10][C@@H:11]1[C:17](=[O:18])[NH:16][C:15]2[CH:19]=[CH:20][CH:21]=[CH:22][C:14]=2[O:13][CH2:12]1)([CH3:7])([CH3:6])[CH3:5]>>[C:4]([O:8][C:9](=[O:23])[NH:10][C@@H:11]1[C:17](=[O:18])[N:16]([CH2:2][CH3:3])[C:15]2[CH:19]=[CH:20][CH:21]=[CH:22][C:14]=2[O:13][CH2:12]1)([CH3:7])([CH3:5])[CH3:6]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 18599719(S)-tert-Butyl (4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)carbamate

Product 1

HCID 57617719HCID 57617719, compound

Procedure

In an analogous manner to that described in example 5d), the alkylation by iodoethane of (S)-(8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl)-carbamic acid tert-butyl ester [Chem.Pharm.Bull. 1986, 34(3), 1128–47] yielded (87% of theory) the title compound as a white solid, m.p.: 112° C., MS m/e (%): 307.1 (M+H+, 93).

Sources & evidence

ORD record: ord-f2497da24ec44a7d82374b17da691dc5
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211573B2

Reaction notes

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