反应详情

温度

60 °C

To 17.1 g (48.5 mmol) racemic (2R,3S and 2S,3R)-3-cyclopropyl-2-dibenzylamino-3-hydroxy-propionic acid ethyl ester in 446 ml tetrahydrofurane were added 8.22 g (194 mmol) lithium hydroxide monohydrate dissolved in 74 ml water. The mixture was stirred at 60° C. overnight. The organic solvent was removed by distillation. Sodium dihydrogenphosphate was added followed by extraction with ethyl acetate. Chromatography on silicagel with diethylether/heptane (1:1 to 1:0) yielded 9.03 g (57%) racemic (2R,3S and 2S,3R)-3-cyclopropyl-2-dibenzylamino-3-hydroxy-propionic acid, MS m/e (%): 326.1 (M+H+, 100).

1. customThe organic solvent was removed by distillation
2. additionSodium dihydrogenphosphate was added
3. extractionfollowed by extraction with ethyl acetate