Lithium Hydroxide → HCID 21091408, compound

HRID 1348636Notes

Reaction equation

HRID 1348636 reaction equation
C([O:3][C:4](=[O:19])[C:5]([OH:18])([CH3:17])[C:6]([NH:8][CH2:9][C:10]([F:16])([F:15])[C:11]([F:14])([F:13])[F:12])=[O:7])C.[OH-].[Li+]>O1CCCC1.O>[OH:18][C:5]([CH3:17])([C:6]([NH:8][CH2:9][C:10]([F:15])([F:16])[C:11]([F:12])([F:14])[F:13])=[O:7])[C:4]([OH:19])=[O:3]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 86605288HCID 86605288, compound

Product 1

HCID 21091408HCID 21091408, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2.91 g (9.93 mmol) 2-hydroxy-2-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid ethyl ester in 50 ml of tetrahydrofurane were added 0.42 g (9,92 mmol) of lithium hydroxide in 20 ml of water and the mixture was stirred overnight at room temperature. After concentration in vacuo water (50 ml) was added and the mixture was acidified to pH 1. Extraction with ethylacetate gave 2.46 g (94%) of the title compound as a solid, MS m/e (%): 263.9 (M−H, 100).

Workup

  1. concentrationAfter concentration in vacuo water (50 ml)
  2. additionwas added
  3. extractionExtraction with ethylacetate

Sources & evidence

ORD record
ord-e6ba9f4284eb45ec9709f5dcaa2179e5
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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