Phosphoric Acid → HCID 67077056, compound

HRID 1348648Notes

Reaction equation

HRID 1348648 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[O:10][C@@H:9]1[CH2:20][CH3:21])(C)(C)C.P(=O)(O)(O)O>O1CCCC1>[NH2:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[O:10][C@@H:9]1[CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 67076914HCID 67076914, compound

Product 1

HCID 67077056HCID 67077056, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared in 81% yield by reaction of 460 mg (1.50 mmol) ((6R,7S)-6-ethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl)-carbamic acid tert-butyl ester with 2.23 g (22.5 mmol) ortho phosphoric acid in 4 ml tetrahydrofurane, MS m/e (%): 207.1 (M+H+, 100).

Sources & evidence

ORD record
ord-88a35be08be443e4bb609f12e7605c3e
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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