反应详情

温度

60 °C

To 17.7 g (51.9 mmol) racemic (2S,3R and 2R,3S)-2-dibenzylamino-3-hydroxy-pentanoic acid ethyl ester in 245 ml tetrahydrofurane were added 8.80 g (208 mmol) lithium hydroxide monohydrate dissolved in 44 ml water. The mixture was stirred at 60° C. for 2.5 days and the organic solvent was removed by distillation. Water was added followed by extraction with diethylether. The waterphase was adjusted to pH 1. Extraction with ethylacetate yielded 14.8 g (91%) racemic (2S,3R and 2R,3S)-2-dibenzylamino-3-hydroxy-pentanoic acid, MS m/e (%): 314.1 (M+H+, 100).

1. customthe organic solvent was removed by distillation
2. additionWater was added
3. extractionfollowed by extraction with diethylether
4. extractionExtraction with ethylacetate