Propargylamine → 2-isobutyl-6-[4-(methylthio)phenyl]-4-propargylaminomethyl-2H-pyridazin-3-one

HRID 1348747Notes

Reaction equation

HRID 1348747 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12]OS(C)(=O)=O)=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([S:24][CH3:25])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3].[CH2:26]([NH2:29])[C:27]#[CH:28]>>[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][NH:29][CH2:26][C:27]#[CH:28])=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([S:24][CH3:25])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 219914882-isobutyl-4-methanesulfonyloxymethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

Product 1

HCID 99241192-isobutyl-6-[4-(methylthio)phenyl]-4-propargylaminomethyl-2H-pyridazin-3-oneYield 52.2%

Procedure

Following the procedure of Example 1(10), 2-isobutyl-4-methanesulfonyloxymethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one and propargylamine were reacted to yield the title compound as a yellow oil (yield: 52.2%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2730924445334ddb9241521fc87d39f2
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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