Ethanol → HCID 58859176, compound

HRID 1349488Notes

Reaction equation

[F:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][NH:7][C:8]([C:10]2O[CH:12]=[C:13]([C:25](=[O:30])[C:26]([CH3:29])([CH3:28])[CH3:27])[C:14](=[O:24])[C:15]=2[O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:9])=[CH:4][CH:3]=1.C(O)C.[CH3:36][O:37][CH:38]([O:41][CH3:42])[CH2:39][NH2:40]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([C:10]2[N:40]([CH2:39][CH:38]([O:41][CH3:42])[O:37][CH3:36])[CH:12]=[C:13]([C:25](=[O:30])[C:26]([CH3:27])([CH3:28])[CH3:29])[C:14](=[O:24])[C:15]=2[O:16][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:9])=[CH:31][CH:32]=1

Participants

Conditions

Temperature: 70 °C

Procedure

To a solution of 3-benzyloxy-5-(2,2-dimethylpropionyl)-4-oxo-4H-pyran-2-carboxylic acid 4-fluorobenzylamide (0.13 g) in tetrahydrofuran (0.5 ml)-ethanol (0.5 ml) was added aminoacetaldehyde dimethyl acetal (0.033 ml) and the mixture was stirred at 70° C. for 3 days. After cooling to room temperature, the solvent was evaporated to give 3-benzyloxy-1-(2,2-dimethoxyethyl)-5-(2,2-dimethylpropionyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 4-fluorobenzylamide (157 mg).

Workup

temperatureAfter cooling to room temperature
customthe solvent was evaporated

Sources & evidence

ORD record: ord-5d82f9af7c874247bd0f776087e46d73
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211572B2

Reaction notes

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