HCID 22479733, compound → HCID 22479881, compound

HRID 1349661Notes

Reaction equation

HRID 1349661 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]#[N:19])[CH:16]=3)[N:11](C3CCCCO3)[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCCC1.Cl>[C:1]1(/[CH:7]=[CH:8]/[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]#[N:19])[CH:16]=3)[NH:11][N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 22479733HCID 22479733, compound

Product 1

HCID 22479881HCID 22479881, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by hydrolyzing 3-((1E)-2-phenylvinyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile (0.268 g, 0.815 mmol) in a mixture of 6 mL of tetrahydrofuran and 6 mL of aqueous hydrogen chloride (6.0 N) at room temperature for 12 hours, and reflux temperature for 6 hours. The compound was used without further purification. ES-MS (m/z) 246 [M+1]+.

Workup

  1. temperaturereflux temperature for 6 hours
  2. customThe compound was used without further purification

Sources & evidence

ORD record
ord-a74c96b7a9f640a0962ccf8c136736a2
Source dataset
uspto-grants-2007_05
Patent number
US07211594B2

Reaction notes

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