Ethyl formate → HCID 21094283, compound

HRID 1350074Notes

Reaction equation

HRID 1350074 reaction equation
Cl.[NH2:2][CH2:3][CH:4]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:17](OCC)=[O:18]>C(OCC)(=O)C>[CH:17]([NH:2][CH2:3][CH:4]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)[C:5]([O:7][CH3:8])=[O:6])=[O:18]

Participants

4

Reactant 2

HCID 8025Ethyl formateHCID 21094281HCID 21094281, compound

Product 1

HCID 21094283HCID 21094283, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound obtained in Step B (20.25 g; 0.08 mol), in the form of a base, is dissolved in 130 ml of ethyl formate (1.81 mol). The reaction mixture is heated at reflux for 6 hours and then evaporated under reduced pressure. The oil obtained is taken up in ethyl acetate. The organic phase is washed with basic water (NaHCO3), dried over magnesium sulphate, filtered and evaporated to yield the title product in the form of a yellow oil.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 6 hours
  3. customevaporated under reduced pressure
  4. customThe oil obtained
  5. washThe organic phase is washed with basic water (NaHCO3)
  6. dry with materialdried over magnesium sulphate
  7. filtrationfiltered
  8. customevaporated

Sources & evidence

ORD record
ord-5d40ec6490de4f3690e319ecf629a268
Source dataset
uspto-grants-2007_05
Patent number
US07214689B2

Reaction notes

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