Hydrochloric Acid → 773897-10-2

HRID 1350076Notes

Reaction equation

HRID 1350076 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[N:9][CH2:8][CH:7]2[C:14]([O:16][CH3:17])=[O:15].Cl>CO.CCOCC.[Pd]>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH2:10][NH:9][CH2:8][CH:7]2[C:14]([O:16][CH3:17])=[O:15]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 21094286HCID 21094286, compound

Product 1

HCID 21094284773897-10-2

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

The compound obtained in Step D (9.21g), in the form of a base, is dissolved in 150 ml of methanol and then palladium-on-carbon (900 mg) is added to the solution. The reaction mixture is stirred at ambient temperature under hydrogen for 4 hours. After removal of the palladium-on-carbon by filtration, the organic phase is evaporated under reduced pressure. The oil obtained is taken up in ether saturated with HCl. The precipitate formed is suction-filtered off and recrystallised from acetonitrile to yield the title product in the form of a white solid.

Workup

  1. customAfter removal of the palladium-on-carbon
  2. filtrationby filtration
  3. customthe organic phase is evaporated under reduced pressure
  4. customThe oil obtained
  5. customThe precipitate formed
  6. filtrationis suction-filtered off
  7. customrecrystallised from acetonitrile

Sources & evidence

ORD record
ord-2314adbefcd24f89a8ba6b483ab38db5
Source dataset
uspto-grants-2007_05
Patent number
US07214689B2

Reaction notes

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