Methylamine → HCID 58861256, compound

HRID 1350581Notes

Reaction equation

HRID 1350581 reaction equation
[F:1][C:2]1([CH2:18][CH2:19][N:20]2[C:24](=[O:25])[CH2:23][O:22][C:21]2=[O:26])[CH2:7][CH2:6][N:5]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH2:4][CH2:3]1.[CH3:27][NH2:28]>O1CCCC1>[F:1][C:2]1([CH2:18][CH2:19][NH:20][C:21](=[O:26])[O:22][CH2:23][C:24]([NH:28][CH3:27])=[O:25])[CH2:3][CH2:4][N:5]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 21096971HCID 21096971, compound

Product 1

HCID 58861256HCID 58861256, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The process is performed according to the procedure described in Example 1 (step 1.5). Starting with 0.52 g (1.46 mmol) of 3-{2-[4-fluoro-1-(2-quinolyl)-4-piperidyl]ethyl}-1,3-oxazolidine-2,4-dione, obtained in step 12.8, and 3.6 ml (7.28 mmol) of a solution (2M) of methylamine in tetrahydrofuran, and after chromatography on silica gel, eluting with a 99/1 mixture of ethyl acetate and methanol, followed by crystallization from diethyl ether, 0.390 g of pure product is obtained in the form of a white solid.

Sources & evidence

ORD record
ord-8829f9fa27374395ae962eb989ca067f
Source dataset
uspto-grants-2007_05
Patent number
US07214798B2

Reaction notes

Loading…