Piperidine → HCID 131726440, compound

HRID 1350601Notes

Reaction equation

HRID 1350601 reaction equation
N1CCCCC1.[NH:7](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:8]([C:13]([NH:15][C@H:16]([C:18]([NH:20][C@H:21]([C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:22][CH:23]([CH3:25])[CH3:24])=[O:19])[CH3:17])=[O:14])[CH2:9][CH2:10][S:11][CH3:12]>CN(C=O)C>[NH2:7][C@H:8]([C:13]([NH:15][C@H:16]([C:18]([NH:20][C@H:21]([C:26]([O:28][CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)=[O:27])[CH2:22][CH:23]([CH3:24])[CH3:25])=[O:19])[CH3:17])=[O:14])[CH2:9][CH2:10][S:11][CH3:12]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 131726438HCID 131726438, compound

Product 1

HCID 131726440HCID 131726440, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a round bottom flask (25 mL), Fmoc-Met-Ala-Leu-OBn is dissolved in 5 mL of anhydrous DMF. Piperidine is added to the solution and the mixture is stirred at room temperature for 25 minutes. The reaction is quenched with water and extracted with ethyl acetate. The combined organic layer is further washed by water, brine and dried over sodium sulfate. Solid Met-Ala-Leu-OBn is obtained after removal of solvent.

Workup

  1. customThe reaction is quenched with water
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layer is further washed by water, brine
  4. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-854995c8d9c446da9c3689e66050b221
Source dataset
uspto-grants-2007_05
Patent number
US07214663B2

Reaction notes

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