Acetone → HCID 23077311, compound

HRID 1350608Notes

Reaction equation

HRID 1350608 reaction equation
[CH3:1][C:2](C)=O.[F:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([F:17])[C:14]=2[F:16])[CH:9]=[CH:8][C:7]=1[OH:18].C(=O)([O-])[O-].[K+].[K+].C(I)C>C1(C)C=CC=CC=1>[CH2:1]([O:18][C:7]1[CH:8]=[CH:9][C:10]2[C:15](=[C:14]([F:16])[C:13]([F:17])=[CH:12][CH:11]=2)[C:6]=1[F:5])[CH3:2]

Participants

6

Reactant 4

HCID 180AcetoneHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 230773061,7,8-Trifluoronaphthalen-2-ol

Product 1

HCID 23077311HCID 23077311, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

An acetone (80 ml) solution of 1,7,8-trifluoro-2-naphthol (15 g), potassium carbonate (16 g), and ethyl iodide (26 g) was stirred for 10 hours at room temperature. Toluene (200 ml) was added in this reaction solution. The organic layer was removed, and the aqueous layer was extracted with toluene. The organic layers were combined, washed with brine, and concentrated. The residue was evaporated under reduced pressure, and 2-ethoxy-1,7,8-trifluoronaphthalene was obtained.

Workup

  1. customThe organic layer was removed
  2. extractionthe aqueous layer was extracted with toluene
  3. washwashed with brine
  4. concentrationconcentrated
  5. customThe residue was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c21c67302d004c128768a2f166002c3a
Source dataset
uspto-grants-2007_05
Patent number
US07214835B2

Reaction notes

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