反应详情

A mixture of N-(4-cyano-2,6-difluorophenyl)methanesulfonamide (1.01 g, 4.35 mmol) in methanol (15 ml), tetrahydrofuran (15 ml) and 12 M aqueous solution of hydrogen chloride (5 ml) was hydrogenated over 10% palladium-carbon (250 mg) under ballon pressure for 3 h at ambient temperature. The catalyst was filtered through a pad of celite and the filter cake was washed with methanol. After the filtrate and washings were evaporated in vacuo, the residue was recrystallized from methanol and diisopropyl ether to give to furnish 953 mg (80% yield) of the title compound as a white solid.

1. filtrationThe catalyst was filtered through a pad of celite
2. washthe filter cake was washed with methanol
3. customAfter the filtrate and washings were evaporated in vacuo
4. customthe residue was recrystallized from methanol and diisopropyl ether
5. customto give