反应详情

温度

65 °C

To an acetone (100 mL) solution of tert-butyl 4-tert-butyl-3-hydroxyphenyl carbonate (J. Org. Chem. 2001, 66, 3435) (5.5 g, 20.7 mmol) were added potassium carbonate (8.6 g, 63 mmol) and benzyl bromide (3.0 ml, 25.0 mmol). The stirred mixture was refluxed at 65° C. for 4 hours. The precipitate was filtered off and washed with acetone. The filtrate was concentrated under reduced pressure to give a residue, which was applied to a silica gel chromatography column and eluted with ethyl acetate/hexane= 1/30 to furnish 7.1 g (96% yield) of the title compound as a colorless oil.

1. filtrationThe precipitate was filtered off
2. washwashed with acetone
3. concentrationThe filtrate was concentrated under reduced pressure
4. customto give a residue, which
5. washeluted with ethyl acetate/hexane= 1/30