Diisopropylethylamine → HCID 21098030, compound

HRID 1351165Notes

Reaction equation

HRID 1351165 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[CH3:13][S:14]([C:17]1[N:22]=[C:21]2[N:23]([CH3:33])[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=3)[C:20]2=[CH:19][N:18]=1)(=[O:16])=[O:15].CCN(C(C)C)C(C)C>C(Cl)Cl>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:32][C:29]1[CH:28]=[CH:27][C:26]([C:25]2[C:20]3[C:21](=[N:22][C:17]([S:14]([CH3:13])(=[O:16])=[O:15])=[N:18][CH:19]=3)[N:23]([CH3:33])[N:24]=2)=[CH:31][CH:30]=1)(=[O:11])=[O:10]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27342222,3-Dichlorobenzene-1-sulfonyl chlorideHCID 21098067HCID 21098067, compound

Product 1

HCID 21098030HCID 21098030, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2,3-Dichlorobenzenesulfonyl chloride (342 mg, 1.5 equiv.) was added to a mixture of 4-(6-Methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl amine (283 mg., 0.93 mmol) and DIEA (325 μl, 2 equiv.) in CH2Cl2 (10 ml) at room temperature. After 2 hrs, the mixture was diluted by CH2Cl2 (10 ml) and washed by 10% NaHCO3, brine, drying and concentration left 420 mg as a golden yellow solid; LC/MS(m/e)=512.0 (MH+).

Workup

  1. washwashed by 10% NaHCO3, brine
  2. customdrying
  3. concentrationconcentration
  4. waitleft 420 mg as a golden yellow solid

Sources & evidence

ORD record
ord-2b6fc38788ac423ab20b06de71bd9a71
Source dataset
uspto-grants-2007_05
Patent number
US07217710B2

Reaction notes

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