1-(4-Fluorophenyl)piperazine → 3-[4-(4-Fluorophenyl)-piperazine-1-sulfonyl]5,6-dihydro-4H-benzo[b]thiophene-7-one

HRID 1351273Notes

Reaction equation

HRID 1351273 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[O:14]=[C:15]1[C:20]2[S:21][CH:22]=[C:23]([S:24](Cl)(=[O:26])=[O:25])[C:19]=2[CH2:18][CH2:17][CH2:16]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([S:24]([C:23]3[C:19]4[CH2:18][CH2:17][CH2:16][C:15](=[O:14])[C:20]=4[S:21][CH:22]=3)(=[O:25])=[O:26])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

Product 1

HCID 210986033-[4-(4-Fluorophenyl)-piperazine-1-sulfonyl]5,6-dihydro-4H-benzo[b]thiophene-7-one

Procedure

From 1-(4-fluorophenyl)-piperazine (91 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (120 mg), the title compound (148 mg) was obtained as a colorless solid, in the same way as Preparation Example 41.

Sources & evidence

ORD record
ord-481339da71ad4265b6e5bef4df31bd50
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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