反应详情

A solution of 5-chlorothiophene-3-sulfonic acid [2-(4-fluorophenyl)ethyl]amide (739 mg), vinyltributyltin (772 mg), cesium fluoride (740 mg), and bis(trit-butylphosphine)palladium (34 mg) in 1,4-dioxane (9 mL) was heated at 100° C. for 16 hours. After the reaction solution was cooled to room temperature, this solution was diluted with ethyl acetate, the resulting insoluble matter was removed by Celite filtration, and washed with ethyl. The residue resulting from the removal of the solvent by evaporation was purified by silica gel column chromatography (hexane/ethyl acetate), and the title compound (328 mg) was obtained as a yellow oily substance.

1. customthe resulting insoluble matter was removed by Celite filtration
2. washwashed with ethyl
3. customThe residue resulting from the removal of the solvent by evaporation
4. customwas purified by silica gel column chromatography (hexane/ethyl acetate)