Sodium Carbonate → 1,1-Dimethylethyl 4-[3-(2-methylpropyl)-1,2,4-oxadiazol-5-yl]-1-piperidinecarboxylate

Isovaleronitrile (14.1 g, 170 mmol) and hydroxylamine hydrochloride (60 g, 850 mmol) were heated under reflux in methanol (300 ml) and water (300 ml) for 5 hours. The reaction mixture was cooled to room temperature, solid sodium carbonate added cautiously and the mixture filtered. The filtrate was concentrated under reduced pressure and extracted with dichloromethane (3×). The combined organic solutions were washed with water and brine, dried (MgSO4), filtered and concentrated under reduced pressure to give a white solid, 15.5 g. In a separate flask 1-(tert-butoxycarbonyl)4-piperidinecarboxylic acid (250 mg, 1.09 mmol) in dichloromethane (5 ml) was treated with diisopropylethylamine (0.28 ml, 2.70 mmol). Bis(tetramethylene)fluoroformamidinium hexafluorophosphate (413 mg, 1.31 mmol) in dichloromethane (5 ml) was added to the solution and stirred at room temperature for 1 hour. A portion of the intermediate white solid (150 mg, 1.31 mmol) and diisopropylethylamine (0.23 ml, 1.09 mmol) in dichloromethane (2 ml) were added, the resulting solution was stirred at room temperature for 16 hours, then heated to 50° C. to concentrate the solution. Dioxane (10 ml) was added and the solution heated to 120° C. for 3 hours. The reaction was cooled to room temperature, diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate solution and 1M citric acid solution. The combined organic solutions were dried (MgSO4), filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using ethyl acetate: pentane (25:75) as eluant to afford the title compound as an oil, 209 mg.

1. filtrationthe mixture filtered
2. concentrationThe filtrate was concentrated under reduced pressure
3. extractionextracted with dichloromethane (3×)
4. washThe combined organic solutions were washed with water and brine
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customto give a white solid, 15.5 g
9. stirringthe resulting solution was stirred at room temperature for 16 hours
10. temperatureheated to 50° C.
11. concentrationto concentrate the solution
12. additionDioxane (10 ml) was added
13. temperaturethe solution heated to 120° C. for 3 hours
14. temperatureThe reaction was cooled to room temperature
15. additiondiluted with ethyl acetate
16. washwashed with saturated aqueous sodium bicarbonate solution and 1M citric acid solution
17. dry with materialThe combined organic solutions were dried (MgSO4)
18. filtrationfiltered
19. customevaporated under reduced pressure
20. customThe residue was purified by column chromatography on silica gel

ORD record

ord-e309cb52104c4292917fb7a7ee9e0966

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07217714B1