2-Bromopyrimidine → HCID 9969927, compound

HRID 1351546Notes

Reaction equation

HRID 1351546 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][NH2:20])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:4][CH:3]=1.Br[C:22]1[N:27]=[CH:26][CH:25]=[CH:24][N:23]=1.C(N(CC)C(C)C)(C)C>CC(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([N:13]2[CH2:14][CH2:15][CH:16]([CH2:19][NH:20][C:22]3[N:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:17][CH2:18]2)(=[O:11])=[O:12])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 783452-BromopyrimidineHCID 81531DiisopropylethylamineHCID 22135614HCID 22135614, compound

Product 1

HCID 9969927HCID 9969927, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 0.3 g of C-{1-[2-(4-Fluoro-phenyl)-ethanesulfonyl]-piperidin-4-yl}-methylamine, 0.3 g of 2-bromopyrimidine, 25 mL of 2-propanol and 0.3 mL of N,N-diisopropylethylamine was heated to reflux overnight. Purification of the residue obtained after concentration under reduced pressure by preparative chromatography, eluting with ethyl acetate gave a white solid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customPurification of the residue
  4. customobtained
  5. concentrationafter concentration under reduced pressure by preparative chromatography
  6. washeluting with ethyl acetate
  7. customgave a white solid

Sources & evidence

ORD record
ord-06daeff0be9349f18f1aada1a96d45fb
Source dataset
uspto-grants-2007_05
Patent number
US07217716B2

Reaction notes

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