反应详情

A mixture of 0.3 g of C-{1-[2-(4-Fluoro-phenyl)-ethanesulfonyl]-piperidin-4-yl}-methylamine, 0.3 g of 2-bromopyrimidine, 25 mL of 2-propanol and 0.3 mL of N,N-diisopropylethylamine was heated to reflux overnight. Purification of the residue obtained after concentration under reduced pressure by preparative chromatography, eluting with ethyl acetate gave a white solid.

1. temperaturewas heated
2. temperatureto reflux overnight
3. customPurification of the residue
4. customobtained
5. concentrationafter concentration under reduced pressure by preparative chromatography
6. washeluting with ethyl acetate
7. customgave a white solid