反应详情

温度

90 °C

4-Bromo-3-methylbenzenesulfonyl chloride (1.145 g, 4.25 mmol) was added portion wise to a solution of sodium sulfite (0.578 g, 2.29 mmol) and sodium hydrogen carbonate (0.749 g, 2.4 mmol) in water (10 mL) at 80° C. The reaction was heated to 90° C. for 3 h. The cooled reaction mixture was evaporated in vacuo to half-volume, at which point a precipitate appeared. This was removed by filtration. The filtrate was concentrated further then cooled to 5° C. and the precipitate removed by filtration. The combined residues were washed with water and dried to give sodium 4-bromo-3-methylbenzenesulfinate (0.54 g).

1. customThe cooled reaction mixture
2. customwas evaporated in vacuo to half-volume, at which point a precipitate
3. customThis was removed by filtration
4. concentrationThe filtrate was concentrated further
5. temperaturethen cooled to 5° C.
6. customthe precipitate removed by filtration
7. washThe combined residues were washed with water
8. customdried