反应详情

To a solution of 7-methoxy-1H-indazole (2.60 g, 17.5 mmol) in N,N-dimethylformamide (50 mL) are added iodine (6.68 g, 26.3 mmol) and potassium hydroxide (2.79 g, 49.7 mmol), and the mixture is stirred at room temperature for 0.5 hour. The reaction solution is poured into a 10% aqueous sodium hydrogen sulfite solution (200 mL), and the mixture is extracted with diethyl ether. The organic layer is washed with water and a saturated brine, and dried over anhydrous magnesium sulfate. The solvent is evaporated under reduced pressure, and the obtained residue is purified by silica gel column chromato-graphy (n-hexane/ethyl acetate=5/1) to give the title compound (3.97 g, yield: 83%).

1. extractionthe mixture is extracted with diethyl ether
2. washThe organic layer is washed with water
3. dry with materiala saturated brine, and dried over anhydrous magnesium sulfate
4. customThe solvent is evaporated under reduced pressure
5. customthe obtained residue is purified by silica gel column chromato-graphy (n-hexane/ethyl acetate=5/1)