Pentanal → HCID 17838093, compound

HRID 1352131Notes

Reaction equation

HRID 1352131 reaction equation
O.Cl.[NH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.[CH:10](=O)[CH2:11][CH2:12][CH2:13][CH3:14].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[NH2:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[NH:36][N:35]=[CH:34]2.C(=O)([O-])O.[Na+]>CO>[NH:36]1[C:37]2[C:33](=[CH:32][C:31]([NH:30][CH:6]3[CH2:7][CH2:8][N:3]([CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:4][CH2:5]3)=[CH:39][CH:38]=2)[CH:34]=[N:35]1

Participants

7

Reactant 5

HCID 8063PentanalHCID 880121H-Indazol-5-amineHCID 516892Sodium BicarbonateHCID 2723901PiperonylamineHCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 17838093HCID 17838093, compoundYield 1.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Piperidone hydrochloride monohydrate (77 mg) and valeraldehyde (43 mg) were dissolved in methanol (1 ml), and sodium triacetoxyborohydride (106 mg) was added to the solution. The reaction mixture was stirred at room temperature for 18 hr. Further, 5-aminoindazole (54 mg) was added thereto. The mixture was stirred for 30 min, and a borane-pyridine complex (0.05 ml) was added thereto. The reaction mixture was stirred at room temperature for 18 hr. A saturated aqueous sodium hydrogencarbonate solution (1 ml) was then added, and the mixture was extracted with chloroform-propanol (3/1). The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure. The residue was purified by HPLC [g chloroform/methanol] to give the title compound (2 mg).

Workup

  1. stirringThe mixture was stirred for 30 min
  2. additiona borane-pyridine complex (0.05 ml) was added
  3. stirringThe reaction mixture was stirred at room temperature for 18 hr
  4. extractionthe mixture was extracted with chloroform-propanol (3/1)
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was removed by distillation under the reduced pressure
  7. customThe residue was purified by HPLC [g chloroform/methanol]

Sources & evidence

ORD record
ord-7af0bdacf89b4a09beb348645c6da83f
Source dataset
uspto-grants-2007_05
Patent number
US07217722B2

Reaction notes

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