反应详情

To 5.52 mmol 2-tert-butoxy-5-methanesulfonyl-benzoic acid methyl ester in 25 ml THF was added a solution of 8.34 mmol lithium hydroxide monohydrate in 25 ml water and the reaction mixture was stirred at room temperature for 4 hours. After such time the THF was removed in vacuo and to the remaining aqueous solution was added 8 ml of 1 N aq HCl leading to precipitation of the compound. The precipitate was filtered off and washed several times with water to yield the title compound (67%) as a white solid. MS (m/e): 289.9 (M+NH4+).

1. customAfter such time the THF was removed in vacuo and to the remaining aqueous solution
2. additionwas added 8 ml of 1 N aq HCl leading
3. customto precipitation of the compound
4. filtrationThe precipitate was filtered off
5. washwashed several times with water