(+-)-Methionine → HCID 68471364, compound

HRID 1352725Notes

Reaction equation

HRID 1352725 reaction equation
NC(C(O)=O)CCSC.[CH2:10]([O:12][C:13](=[O:27])[CH2:14][C:15]1[C:24]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]=2[CH:18]=[C:17]([O:25]C)[CH:16]=1)[CH3:11]>CS(O)(=O)=O>[CH2:10]([O:12][C:13](=[O:27])[CH2:14][C:15]1[C:24]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]=2[CH:18]=[C:17]([OH:25])[CH:16]=1)[CH3:11]

Participants

4

Reactant 2

HCID 876(+-)-MethionineHCID 68471521HCID 68471521, compound

Product 1

HCID 68471364HCID 68471364, compound

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Procedure

DL-Methionine (1.11 g, 7.5 mmol) and compound of step b) is dissolved in methanesulfonic acid (9 ml) and kept at RT over night. The reaction is poured into a ice-cold saturated NaCl solution and extracted 3 times with methylene chloride. The organic layer is dried, concentrated and purified on silica gel (methylene chloride/methanol 95/5) affording the pure compound.

Workup

  1. waitkept at RT over night
  2. extractionextracted 3 times with methylene chloride
  3. customThe organic layer is dried
  4. concentrationconcentrated
  5. custompurified on silica gel (methylene chloride/methanol 95/5)
  6. customaffording the pure compound

Sources & evidence

ORD record
ord-bc9e3d5ca1a0465397b1ffb5e7d24907
Source dataset
uspto-grants-2007_05
Patent number
US07220774B2

Reaction notes

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