反应详情

温度

50 °C

To a solution of m-iodophenol (1.22 g, 5.55 mmol) in N,N-dimethylformamide (15 ml) were added potassium carbonate (1.40 g, 10.1 mmol) and t-butyl bromoacetate (1.22 ml, 6.25 mmol), and the mixture was stirred for 3 hours at 50° C. Thereto was added an aqueous 5% potassium hydrogensulfate solution and the mixture was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution, and dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue was purified with silica gel chromatography (hexane:ethyl acetate=4:1) to give the subject compound (1.85 g, 100%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with an aqueous saturated sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. customThe solvent was removed under reduced pressure
5. customthe residue was purified with silica gel chromatography (hexane:ethyl acetate=4:1)