Trifluoroacetic acid → Trifluoroacetate

HRID 1353088Notes

Reaction equation

[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[C:4](=[O:18])[N:3]1[C:19]1[CH:34]=[CH:33][C:22](C(NCCN2CCCC2)=O)=[C:21]([O:35]COC)[CH:20]=1.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>>[OH:35][C:21]1[CH:20]=[C:19]([N:3]2[C:4](=[O:18])[C:5]3[C:10](=[CH:9][CH:8]=[C:7]([O:11][C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:6]=3)[C:2]2=[O:1])[CH:34]=[CH:33][C:22]=1[O:43][CH2:41][CH2:40][N:3]1[CH2:4][CH2:5][CH2:10][CH2:2]1.[F:39][C:40]([F:45])([F:44])[C:41]([O-:43])=[O:42]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 21101404HCID 21101404, compound

Product 2

HCID 84468Trifluoroacetate

HCID 17989380HCID 17989380, compound

Procedure

4-(1,3-Dioxo-5-phenoxy-1,3-dihydro-isoindol-2-yl)-2-methoxymethoxy-N-(2-pyrrolidin-1-yl-ethyl)-benzamide [Example G2] was treated with trifluoroacetic acid (1 ml, 1 M in dichloromethane). After 30 minutes, the solvent was removed to afford the title compound as a trifluoroacetate salt.

Workup

customthe solvent was removed

Sources & evidence

ORD record: ord-035e1e694eef488ba6b1412b19674597
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220777B2

Reaction notes

Loading…