4-Fluorophenyl isocyanate → HCID 21101813, compound

HRID 1353319Notes

Reaction equation

HRID 1353319 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1.CCCCCC.CCOC(C)=O>C1COCC1>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:26]([NH:25][C:22]4[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=4)=[O:27])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 709554-Fluorophenyl isocyanateHCID 21101968HCID 21101968, compoundHCID 21226206Ethyl acetate hexane

Product 1

HCID 21101813HCID 21101813, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-Fluoro-4-(piperazin-1-yl)quinoline (0.29 g, 1.25 mmol) and 4-fluorophenyl isocyanate (142 μL, 1.25 mmol) in THF (10 mL) are reacted according to method C yielding the product as colorless crystals after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-9e2f4ebac1e44e49a13098131b39aaf3
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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